LUMNIA-N is the world’s first manually operated microscope integrating a navigation system. This innovative add-on kit allows for the real time visualization of the location of the inspected magnified image, over a digital-overview image of the sample. The inspected field-of-view appears as a frame onto the overview image, the size of which varies automatically with the magnification. This way, the images of the inspected areas are tagged with their XY coordinates when stored. Moreover, the stored/analyzed image frames are marked onto the overview image for guiding retrieval and for minimizing the risk for missing important areas.